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Pseudoephedrine is a drug found in numerous prescription and behind-the-counter medications, including Sudafed Congestion (but not Sudafed PE), Zyrtec-D, and Claritin-D. It’s used to temporarily relieve nasal congestion from colds, allergies, and hay fever, and temporarily relieve sinus congestion and pressure. Though it can relieve symptoms, pseudo ephedrine doesn’t treat or speed the recovery of the underlying health condition.

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Pseudo ephedrine is in a class of medications called nasal decongestants, which cause smooth muscles around the airway and nasal cavity to relax, allowing more air to flow through. It also causes blood vessels to contract. Pseudo ephedrine is also sometimes used “off label” to treat urinary or stress incontinence, and to prevent ear pain and blockage from pressure changes due to elevation or scuba diving.

Pseudoephedrine (PSE) is a safe and effective active ingredient found in leading cold, allergy, and sinus medicines to provide congestion relief. While over 18 million American families rely on these medicines every year, PSE can also be used in the illegal manufacture of methamphetamine. As a result, some policymakers and law enforcement officials in a number of states support requiring a doctor’s prescription to obtain PSE-containing medicines, even though the vast majority of these medicines are sold to law-abiding consumers.

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Depending on the medication, pseudo ephedrine may be paired with other drugs. For instance, the active components of the allergy medication Zyrtec-D are pseudo ephedrine and the antihistamine cetirizine hydrochloride. Advil Cold and Sinus contains pseudo ephedrine and ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) for pain and swelling. Pseudoephedrine can be used to make methamphetamine, or meth, a powerful and highly addictive stimulant. For many years, the drug was available over-the-counter (OTC) without prescription or restrictions.

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